张崇敬，1983年生，籍贯山东临朐，药物化学家，药物研究所研究员，博士生导师。2001年考入山东大学药学专业，2005年获得学士学位。2005-2008年在老虎机游戏药物所药物化学专业攻读硕士学位，从事合成药物化学研究。2009-2013年在新加坡国立大学化学专业攻读博士学位，从事药物化学生物学研究。2013年进入新加坡国立大学化学与生物工程系进行博士后研究工作，主要研究小分子荧光探针的开发。2017年升为研究员。

化学生物学和创新药物发现：利用化学蛋白质组学技术，阐明活性分子的蛋白靶标和作用机制，开展机制指导的先导化合物发现；设计、合成小分子荧光探针，用于先导化合物的发现。

老虎机游戏

1. Liu, S.#; Wei, C.#; Liu, T.#; Ma, S.-G.#; Chen, C.; Lin, H.; Zhang, L.; Wang, H.*; Zhang, C.-J.*; Yu, S.-S.* A heme-activatable probe and its application in the high-throughput screening of Plasmodium falciparum ring-stage inhibitors. Signal Transduct Target Ther, 2022, 7, 160. (IF=38.126).

2. Ye, Z.#; Wang, K.#; Chen, L.; Jin, X.; Chen, H.; Tang, G.; Yao, S.Q.; Feng, Z.*; Zhang, C.-J.* A targeted covalent inhibitor of p97 with proteome-wide selectivity. Acta Pharm. Sin. B. 2022, 12, 982-989. (IF=14.903).

3. Chen, L.; Wang, H.; Ji, T.-F.*; Zhang, C.-J.* Chemoproteomics-based target profiling of sinomenine reveals multiple protein regulators of inflammation”. Chem. Commun., 2021, 57, 5981-5984. (IF=6.065).

4. Zhao, C.; Liu, T.; Xu, M.; Lin, H.; Zhang, C.-J.* A fundamental study on the fluorescence-quenching effect of nitro groups in tetraphenylethene AIE dyes with electron-withdrawing groups”. Chin. Chem. Lett. 2021, 32, 1925-1928. (IF=6.779).

5. Wei, C.; Zhao, C.; Liu, S.; Zhao, J.; Ye, Z; Wang, H.*; Yu, S.*; Zhang, C.-J.* Activity-based protein profiling reveals thatsecondary-carbon-centered radicals of synthetic 1,2,4-trioxolanes are predominately responsible for modification of protein targets in malaria parasites. Chem. Commun., 2019, 55, 9535. (IF=5.996).

6. Lin, H.; Yang, H.; Huang, S.; Wang, F.; Wang, D.-M.; Liu, B*.; Tang, Y.-D*.; Zhang, C.-J*. Caspase?1 Specific Light-Up Probe with Aggregation-Induced Emission Characteristics for Inhibitor Screening of Coumarin-Originated Natural Products. ACS Appl. Mater. Interfaces. 2018, 10, 12173?12180. (IF=8.456).

7. Feng, G.; Liu, J.; Zhang, C.-J*.; Liu, B*. Artemisinin and AIEgen Conjugate for Mitochondria-Targeted and Image-Guided Chemo- and Photodynamic Cancer Cell Ablation. ACS Appl. Mater. Interfaces. 2018, 10, 11546?11553. (IF=8.456).

8. Zhang, C.-J.#; Wang, J.#*; Zhang, J.; Lee, Y. M.; Feng, G.; Lim, T. K.; Shen, H.; Lin, Q.; Liu, B*. Mechanism-Guided Design and Synthesis of Mitochondria-targeting Artemisinin Analogue with Enhanced Anticancer Activity. Angew. Chem. Int. Ed., 2016, 55, 13770-13774. (IF=11.994).

9. Zhang, C.-J.; Feng, G.; Xu. S.; Zhu, Z.; Lu. X.; Wu. J.; Liu, B*. Structure-dependent cis/trans Isomerization for Tetraphenylethene Derivatives: Consequences for Aggregation-Induced Emission. Angew. Chem. Int. Ed., 2016, 55, 6192-6196. (IF=11.994).

10. Wang, J. *#; Zhang, C.-J.#; Chia, W. N.; Loh, C. C. Y.; Li, Z.; Lee, Y. Q.; Lee, Y. M.; He, Y.; Yuan, L.; Liu, M.; Liew, C. X.; Zhang, J.; Lim, T. K.;  Lim, C. K.; Shen, H. M.; Tan, K. S. W. *; Lin, Q. S*. Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat. Commun, 2015, 6, 10111. (IF=11.329, C100, ESI, F1000).