王朝辉，研究员，博士生导师。2006年毕业于郑州大学，获得药物制剂学士学位。2009年毕业于沈阳药科大学，获得药剂学硕士学位。2012年毕业于北京大学，获得药剂学博士学位。2012年07月-2020年08月先后在美国普渡大学、德克萨斯大学西南医学中心从事科学研究工作。2020年10月作为“高层次引进人才”入职中国医学科院-老虎机游戏药物研究所，任研究员、课题组长。

智能药物输送系统的研究，生物大分子递送系统的研究，肿瘤联合免疫治疗。

老虎机游戏

1. 王朝辉，刘玉玲*. 抗肿瘤纳米药物的临床转化进展及展望. 药学学报. 2022, 57,134-141;

2. Min Luo#, Hua Wang#, Zhaohui Wang#, Haocheng Cai, Zhigang Lu, Yang Li, Mingjian Du, Gang Huang, Chensu Wang, Xiang Chen, Matthew R. Porembka, Jayanthi Lea, Arthur E. Frankel, Yang-Xin Fu, Zhijian J. Chen*, and Jinming Gao*. A STING-activating nanovaccine for cancer immunotherapy. Nature Nanotechnology. 2017, 12,648-654. (IF=40.523, C100, ESI)

3. Zhaohui Wang#, Min Luo#, Chengqiong Mao, Qi Wei, Tian Zhao, Yang Li, Gang Huang, and Jinming Gao*. A redox-activatable fluorescent sensor for the high-throughput quantification of cytosolic delivery of macromolecules. Angewandte ChemieInternational Edition. 2017, 129, 1339-1343. (IF=16.823)

4. Chukwuemika Aroh#, Zhaohui Wang#, Nicole Dobbs, Min Luo, Zhijian Chen*, Jinming Gao*, and Nan Yan*. Innate immune activation by cGAMP-PC7A nanoparticles leads to potent and long-acting antiretroviral response against HIV-1. Journal of Immunology. 2017, 199, 3840-3848. (IF=5.426)

5. Zhaohui Wang#, Yang Yu, Wenbing Dai, Jingrong Cui, Hounan Wu, Lan Yuan, Hua Zhang, Xueqing, Wang, Jiancheng Wang, Xuan Zhang, and Qiang Zhang*. A specific peptide ligand-modified lipid nanoparticle carrier for the inhibition of tumor metastasis growth. Biomaterials. 2013, 34, 756-764. (IF=15.304)

6. Zhaohui Wang#, Yang Yu, Jie Ma, Haoran Zhang, Hua Zhang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, and Qiang Zhang*. LyP-1 Modification to Enhance Delivery of Artemisinin or Fluorescent Probe Loaded Polymeric Micelles to Highly Metastatic Tumor and Its Lymphatics. Molecular Pharmaceutics. 2012, 9, 2646-2657. (IF=5.364)

7. Zhaohui Wang#, Yang Yu, Wenbing Dai, Jingkai Lu, Jingrong Cui, Hounan Wu, Lan Yuan, Hua Zhang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang*. The use of a tumor metastasis targeting peptide to deliver doxorubicin-containing liposomes to highly metastatic cancer. Biomaterials. 2012, 33, 8451-8460. (IF=15.304)

8. Zhao H. Wang#, Zhan Y. Wang, Chang S. Sun, Chun Y. Wang, Tong Y. Jiang, Si L. Wang*. Trimethylated chitosan-conjugated PLGA nanoparticles for the delivery of drugs to the brain. Biomaterials. 2010, 31, 908-915. (IF=15.304, C100)

9. Stimuli-responsive and triggered drug delivery systems. Amit Singh and Mansoor M Amiji (Ed.); The Royal Society of Chemistry, 51-82. (书籍章节).

10. 成果转化. 开发的疫苗平台已转让OncoNano Medicine, Inc（ONM-500），获得1540万美元的基金资助其临床研究，受邀担任技术顾问。参与开发的肿瘤实时成像探针（ONM-100）已进入临床II期，并获得美国FDA的快速通道审评。