孙永汇，1989年生，籍贯山东青岛，药物化学家，中国医学科学院药物研究所研究员，博士生导师。2008年考入山东大学药学专业，2012年获得学士学位。2012年在清华大学生物学专业攻读博士学位，从事小分子诱导靶向临床难治/耐药蛋白降解（PROTAC）研究。2019年在哈佛大学医学院做交流访问学者，从事新型蛋白降解机制探索研究。2020年进入清华大学进行博士后研究工作，主要研究新型PROTAC/分子胶双机制蛋白降解剂。2020年升为助理研究员。

以克服人类严重疾病为导向，针对临床难治/复发型肿瘤，开发新型小分子诱导不可成药/耐药靶点的选择性降解。基于计算机辅助等技术，开发不可成药靶点的新型抑制剂、新型合成手段及新型生物学化学技术。

老虎机游戏

1. Yonghui Sun#, Xin Luo#, Zimo Yang, Wenxing Lv, Lixia Chen, Hua Li*, and Yu Rao*. Developing potent BTK^C481S PROTACs for ibrutinib-resistant malignant lymphoma. Chinese Chemical Letters. In Press. (2022. IF=8.455)

2. Zimo Yang#, Yonghui Sun#, Zhihao Ni, Celi Yang, Yan Tong, Yujie Liu, Haitao Li, and Yu Rao*. Merging PROTAC and molecular glue for degrading BTK and GSPT1 proteins concurrently. Cell Research. 31(12):1315-1318. (2021. IF=25.617)

3. Yonghui Sun, Yu Rao*. Protein Degradation with New Chemical Modalities: Successful Strategies in Drug Discovery and Chemical Biology (Chapter 8). Drug Discovery, Royal Society of Chemistry ISBN: 978-1-78801-686-5. (2020)

4. Yonghui Sun#, Ning Ding#, Yuqin Song#, Zimo Yang, Wanli Liu*, Jun Zhu*, and Yu Rao*. Degradation of Bruton’s tyrosine kinase mutants by PROTACs for potential treatment of ibrutinib-resistant non-Hodgkin lymphomas. Leukemia 33(8):2105-2110. (2019. IF=8.665)

5. Yonghui Sun#, Xingwang Zhao#, Ning Ding#, Hongying Gao#, Yue Wu, Yiqing Yang, Meng Zhao, Jinseok Hwang, Yuqin Song, Wanli Liu*, and Yu Rao*. PROTAC-induced BTK degradation as a novel therapy for mutated BTK^C481S induced ibrutinib-resistant B-cell malignancies. Cell Research 28(7):779-781. (2018. IF=17.848, C100)

6. Yonghui Sun#, Tianyu Sun#, Yundong Wu, Xinhao Zhang*, and Yu Rao*. A diversity-oriented synthesis of bioactive benzanilides via a regioselective C(sp²)-H hydroxylation strategy. Chemical Science 7(3):2229-2238. (2016. IF=8.668)

7. Xinglin Yang#, Yonghui Sun#, Tianyu Sun, and Yu Rao*. Auxiliary-assisted palladium-catalyzed halogenation of unactivated C(sp³)-H bonds at room temperature. Chemical Communications 52(38):6423-6426. (2016. IF=6.319)

8. Xiuyun Sun#, Yonghui Sun#, and Yu Rao*. Cyclobutanones as useful synthons for the preparation of bioactive molecules and fused-ring chemicals. Current Organic Chemistry 20(18):1878-1901. (2016. IF=2.075)

9 Xiuyun Sun#, Yonghui Sun#, Chao Zhang, and Yu Rao*. Room-temperature Pd-catalyzed C-H chlorination by weak coordination: one-pot synthesis of 2-chlorophenols with excellent regioselectivity. Chemical Communications 50(10):1262-1264. (2014. IF=6.834)