黄海洪，1967年生，籍贯江苏泗洪，药物化学家，药物研究所所研究员，博士生导师。1985年考入北京师范大学化学专业，1989年获得学士学位。1989年在南开大学物理有机化学专业攻读硕士学位，从事芳香有机锂试剂与卤代烃的反应机理研究。2009-2010年在美国特拉华大学化学系做访问学者，主要研究活性天然产物的全合成和结构优化工作。1992年进入药物研究所，主要从事新药研究工作。1995年升为助理研究员。1998年为副研究员。2004年为研究员。

v针对重大疾病耐药结核、恶性肿瘤、代谢性疾病及炎症免疫等治疗领域的创新药物研究，涉及药物分子设计与合成、活性天然产物的结构优化、新药研发项目的跨学科综合管理。

老虎机游戏

1.Hongyi Zhao#, Yongxin Gao#, Wei Li#, Li Sheng#, Keli Cui, Bin Wang, Lei Fu, Meng Gao, Ziyun Lin, Xiaowen Zou, Mary Jackson, Haihong Huang*, Yu Lu*, and Dongfeng Zhang*. Design, Synthesis, and Biological Evaluation of Pyrrole-2-carboxamide Derivatives as Mycobacterial Membrane Protein Large 3 Inhibitors for Treating Drug-Resistant Tuberculosis. J. Med. Chem., 2022, 65(15):10534?10553. (IF=8.039)

2. Rongfei Qin#, Pengxu Wang#, Bin Wang, Lei Fu, Sarah M. Batt, Gurdyal S. Besra, Chengwei Wu, Yanan Wang, Haihong Huang*, Yu Lu*, and Gang Li*. Identification of thiophene-benzenesulfonamide derivatives for the treatment of multidrug-resistant. Eur. J. Med. Chem., 2022, 231, 114145. (IF=7.088)

3. Yongqi Wu, Bin Wang, Haijia Lu, Hongyi Zhao, Beibei Yang, Yu Lu, Dongfeng Zhang*, Ning Sun*, and Haihong Huang*. Identification of Novel Tricyclic Benzo[1,3]oxazinyloxazolidinones as Potent Antibacterial Agents with Excellent Pharmacokinetic Profiles against Drug-Resistant Pathogens. J. Med. Chem., 2021, 64(6):3234?3248. (IF=8.039)

4. Pengxu Wang#, Sarah M. Batt#, Bin Wang, Lei Fu, Rongfei Qin, Yu Lu, Gang Li*, Gurdyal S. Besra*, and Haihong Huang*. Discovery of Novel Thiophene-arylamide Derivatives as DprE1 Inhibitors with Potent Antimycobacterial Activities. J. Med. Chem., 2021, 64(9):6241?6261. (IF=8.039)

5.Dongfeng Zhang#, Peng Li#, Yongxin Gao, Yaoyao Song, Yaqin Zhu, Hong Su, Beibei Yang, Li Li, Gang Li, Ningbo Gong, Yang Lu, Huanjie Shao*, Chunrong Yu*, Haihong Huang*. Discovery of a Candidate Containing an (S)?3,3-Difluoro-1-(4-methylpiperazin-1-yl)-2,3-dihydro?1H?inden Scaffold as a Highly Potent Pan-Inhibitor of the BCR-ABL Kinase Including the T315I-Resistant Mutant for the Treatment of Chronic Myeloid Leukemia. J. Med. Chem., 2021, 64(11):7434?7452. (IF=8.039)

6. Hongyi Zhao, Bin Wang, Lei Fu, Gang Li, Haijia Lu, Yuke Liu, Li Sheng, Yan Li, Baoxi Zhang, Yang Lu, Chen Ma, Haihong Huang*, Dongfeng Zhang* and Yu Lu*. Discovery of a Conformationally Constrained Oxazolidinone with Improved Safety and Efficacy Profiles for the Treatment of Multidrug-Resistant Tuberculosis. J. Med. Chem., 2020, 63(17):9316?9339. (IF=7.446)

7. Peng Li, Bin Wang, Gang Li, Lei Fu, Dongfeng Zhang, Ziyun Lin, Haihong Huang*, and Yu Lu*. Design, synthesis and biological evaluation of diamino substituted cyclobut-3-ene-1,2-dione derivatives for the treatment of drug-resistant tuberculosis. Eur. J. Med. Chem., 2020, 206, 112538. (IF=6.514)

8.Gang Li#, Bingxu Meng#, Baokun Yuan, Yi Huan, Tian Zhou, Qian Jiang, Lei Lei, Li Sheng, Weiping Wang, Ningbo Gong, Yang Lu, Chen Ma, Yan Li, Zhufang Shen*, and Haihong Huang*. The optimization of xanthine derivatives leading to HBK001 hydrochloride as a potent dual ligand targeting DPP-IV and GPR119. Eur. J. Med. Chem., 2020, 188, 112017. (IF=6.514)

9. Peng Li, Bin Wang, Xinwei Zhang, Sarah M. Batt, Gurdyal S. Besra, Tingting Zhang, Chen Ma, Dongfeng Zhang, Ziyun Lin, Gang Li*, Haihong Huang*, and Yu Lu*. Identification of novel benzothiopyranone compounds against Mycobacterium tuberculosis through scaffold morphing from benzothiazinones. Eur. J. Med. Chem., 2018, 160, 157?170. (IF=4.833)

10. Dongfeng Zhang#, Yu Lu#, Kai Liu, Binna Liu, Jingbin Wang, Gang Zhang, Hao Zhang, Yang Liu, Bin Wang, Meiqin Zheng, Lei Fu, Yanyan Hou, Ningbo Gong, Yang Lv, Chun Li, Christopher B. Cooper, Anna M. Upton, Dali Yin, Zhenkun Ma* and Haihong Huang*. Identification of Less Lipophilic Riminophenazine Derivatives for the Treatment of Drug-Resistant Tuberculosis. J. Med. Chem., 2012, 55(19):8409?8417. (IF=5.614)