訾佳辰，1978年生，籍贯河北，天然药物化学家，药物研究所研究员，博士生导师。1997年考入沈阳药科大学中药学专业，2001年获得学士学位。2001年在沈阳药科大学生药学专业攻读硕士学位，从事天然药物化学研究。2005年在中国医学科学院药物研究所药物化学专业攻读博士学位，从事天然药物化学研究。2009-2014先后在美国伊利诺伊大学、犹他州立大学和艾奥瓦州立大学进行博士后研究工作，主要研究天然产物及其生物合成。 2015年升为特聘研究员。2016年为研究员。

植物药效分子的发现和生物合成研究。利用多组学、合成生物学、体外酶法揭示生物合成途径；运用结构生物学以及多尺度模拟，阐明酶机制；基于理性设计进行酶工程改造；构建基于细胞工厂、体外酶法的生物制备方法。

老虎机游戏

1. Wenlong Zha#, Fan Zhang#, Jiaqi Shao, Xingmei Ma, Jianxun Zhu, Pinghua Sun, Ruibo Wu*., Jiachen Zi*. Rationally engineering santalene synthase to readjust the component ratio of sandalwood oil. Nat. Commun. 13: 2508. (IF=17.694)

2. Jianxun Zhu#, Lihong Liu#, Maobo Wu, Guiyang Xia, Pengcheng Lin, and Jiachen Zi*. Characterization of a Sesquiterpene Synthase Catalyzing Formationof Cedrol and Two Diastereoisomers of Tricho-Acorenol from Euphorbia fischeriana. J. Nat. Prod. 84: 1780?1786. (IF=4.803)

3. Jincai Liang#, Tianyue An#, Jian-Xun Zhu, Shan Chen, Jian-Hua Zhu, Reuben J. Peters*, Rongmin Yu*, Jiachen Zi*. Mining of the Catharanthus roseus Genome Leads to Identification of a Biosynthetic Gene Cluster for Fungicidal Sesquiterpenes. J. Nat. Prod. 84: 2709-2716. (IF=4.803)

4. Jiazeng Yang#, Jincai Liang#, Lei Shao, Lihong Liu, Ke Gao, Junliang Zhang, Zhenjiao Sun, Wendong Xu, Pengcheng, Lin, Rongmin Yu, Jiachen Zi*. Green production of silybin and isosilybin by merging metabolic engineering approaches and enzymatic catalysis. Metab. Eng. 59: 44-52. (IF=9.783)

5.Fan Zhang#, Tianyue An#, Xiaowen Tang, Jiachen Zi*, Hai-Bin Luo*, and Ruibo Wu*. Enzyme Promiscuity versus Fidelity in two Sesquiterpene Cyclases (TEAS versus ATAS). ACS Catal. 10: 1470–1484. (IF=12.350)

6. Wenlong Zha#, Tianyue An#, Ting Li, Jianxun Zhu, Ke Gao, Zhenjiao Sun, Wendong Xu, Pengcheng Lin, Jiachen Zi*. Reconstruction of the Biosynthetic Pathway of Santalols under Control of the GAL Regulatory System in Yeast. ACS Synth. Biol. 9(2): 449-456. (IF=5.110)

7. Tianyue An#, Linsheng Li#, Ying Lin, Fanqi Zeng, Pengcheng Lin, Jiachen Zi*. Characterization of guaiene synthases from Stellera chamaejasme L. flowers and their application in de novo production of (-)-rotundone in yeast. J. Agric. Food Chem. 68(10): 3214-3219. (IF=5.279)

8. Rihan Xie, Linsheng Li, Xiaona Fan*, Jiachen Zi*. Euphoractone, a cytotoxic meroterpenoid with an unusual entabietane-phloroglucinol skeleton, from Euphorbia fischeriana Steud. Chin. Chem. Lett. 31(2): 431-433. (IF=6.779)

9. Jiajian Huang#, Wenlong Zha#, Tianyue An, Hua Dong, Ying Huang, Dong Wang, Rongmin Yu, Lixin Duan, Xueli Zhang, Reuben J. Peters*, Zhubo Dai*, Jiachen Zi*. Identification of RoCYP01 (CYP716A155) enables construction of engineered yeast for high-yield production of betulinic acid. Appl. Microbiol. Biotechnol. 103(17): 7029-7039. (IF=3.670)

10. Jian Chen#, Xiaona Fan#, Jianhua Zhu, Liyan Song, Zhiwei Li, Fei Lin, Rongmin Yu*, Hanhong Xu*, Jiachen Zi*. Limonoids from seeds of Azadirachta indica A. Juss. and their cytotoxic activity. Acta Pharm. Sin. B 8(4): 639-644. (IF=6.014)